PERFIL HEPÁTICO EN PACIENTES CON DENGUE IGM POSITIVO DEL ÁREA DE HOSPITALIZACIÓN DEL HOSPITAL VERDI CEVALLOS BALDA DE PORTOVIEJO, ENERO - JULIO DEL 2013

Abstract

The clinical characterization of Dengue is highly variable due to multiple alterations induced by the virus in the body. He has been reported increased levels of transaminases similar to those produced by the Hepatitis virus in patients with Dengue IgM positive. This research was raised in order to establish by means of studies, the determination of alterations in liver function tests in patients with Dengue IgM positive and relate clinical and serologically viral infection. 86 Cases with serology for Dengue IgM positive confirmation was conducted, prothrombin time (PT) and partial thromboplastin time (PTT), quantification of transaminases (ALT and AST).In relation to clinical features 92% of patients with Dengue IgM positive referred abdominal pain, frontal headache, high fever, headaches, retrocular, myalgia and arthralgia, nausea, vomiting, dehydration. According to the gender, infection had no inclination for sex while there was a slight predominance in women. You could be established through surveys and field observation are the main factors (direct contact with the Aedes Aegypti mosquito, little responsibility for the inhabitants of the sector to eliminate breeding sites and other hygiene habits). This research was carried out through the following methodology; foresight, documentary, and field work was based on the collection of data being tabulated, analyzed and interpreted. Leucopenia was observed in the laboratory results (61%) in both forms of Dengue severe thrombocytopenia (< 50.000 × mm3) and TP and TPT elongated in 83%, 71% and 17%, respectively. The value of transaminases was up to five times higher than the normal value (p < 0.005) in 61% of the patients with DC and in 88%, with a predominance of AST in both group. The results suggest liver damage during the course of Dengue. This allows to claim that the Dengue virus infection can cause acute liver dysfunction and should be considered in the differential diagnosis with other viral infections with liver dysfunction